Schizophrenia: A Neurodevelopmental Perspective

The schizophrenia prodrome revisited: a neurodevelopmental perspective.

Despite the widespread acceptance of the neurodevelopmental model of schizophrenia, its application to research concerned with the prodromal phase of illness is limited. Little recognition has been given to the concept of an enduring biological vulnerability to illness that may be responsive to early intervention. Rather, the focus of most prodromal studies is on emerging positive symptoms. The...

Is schizophrenia a neurodevelopmental disorder?

Neurodevelopmental hypothesis of schizophrenia

The neurodevelopmental hypothesis of schizophrenia provided a valuable framework that allowed a condition that usually presents with frank disorder in adolescence or early adulthood to be understood at least in part as a consequence of events occurring early in development. However, the implications of the neurodevelopmental hypothesis for nosological conceptions of the disorder can only now be...

Schizophrenia is (not simply) a neurodevelopmental disorder.

Schizophrenia affects almost 1% of the population at some point in their life. It occurs in all geographic areas in which studies have been done, although the outcome appears to be better in developing countries. In this editorial we will discuss the evidence, from epidemiological, genetic and neuroimaging studies, that suggests that schizophrenia is in part a neurodevelopmental disorder. Howev...

Neurodevelopmental risk factors in schizophrenia.

The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigene...